Dosage Form, Composition & NAFDAC Registration Number (NRN)
Tablet (NRN: A4-7347): Loratadine 10 mg.
Pack size: Blister packs of 2 x 10 and 10 x 10.
Syrup (NRN: A4-7551): Loratadine 5 mg
Pack size: 60 ml Plastic bottle.
Mechanism of action: Competitively antagonizes histamine at the H 1 -receptor site.
Pharmacokinetics: Rapidly absorbed following oral administration. Tmax is 1.3hrs for loratadine and 2.5hrs for its metabolite. Food increases bioavailability (AUC) approximately 40% however, Tmax is delayed by 1hr. Steady state is reached by approximately the fifth dosing day.
Distribution: 97% protein bound.
Metabolism: Metabolite is descarboethoxyloratadine. Metabolized by CYP-450 3A4 and P450 2D6 and it undergoes extensive first-pass metabolism.
Elimination: Approximately 80% equally distributed between urine and feces in the form of metabolic products within 10 days. The t½ for loratadine is 8.4hrs (3 -20hrs). The t½ for descarboethoxyloratadine is 28 hrs (8.8 to 92 hrs).
Loratadine is used for the symptomatic relief of allergic conditions such as sneezing, rhinorrhea, itching, ocular itching and burning. It is also indicated for the relief of chronic urticaria and other allergic dermatological disorders.
Risk-benefit ratio should be considered when the following medical problems exist; bladder neck obstruction, prostatic hypertrophy, urinary retention, glaucoma, or sensitivity to loratadine.
Precaution should be exercised when administering loratadine to patients with severe hepatic impairment as reduced clearance of loratadine may occur
Patients sensitive to one of the antihistamines may be sensitive to others
Safe use of loratadine in pregnancy has not been established
No drug-drug interaction that is considered serious. However, it should not be taken with alcohol.
Sedative and anticholinergic effects are not likely. Headache, nausea and fatigue have been reported. Those reported rarely include; hair loss, changes in liver function and severe allergic reactions.
Dosage & Administration
Adult and children over 6 years: 10 mg daily.
Children 2 – 5 years: One teaspoonful (5 mg) daily.
Patients with severe liver impairment should take one tablet every other day or as directed by the Physician.
Store protected from light.
Keep in a cool dry place and away from children.aibpharma.com
We have a 30-day return policy, which means you have 30 days after receiving your item to request a return.
To be eligible for a return, your item must be in the same condition that you received it, unworn or unused, with tags, and in its original packaging. You’ll also need the receipt or proof of purchase.
To start a return, you can contact us at firstname.lastname@example.org. If your return is accepted, we’ll send you a return shipping label, as well as instructions on how and where to send your package. Items sent back to us without first requesting a return will not be accepted.
Damages and issues Please inspect your order upon reception and contact us immediately if the item is defective, damaged or if you receive the wrong item, so that we can evaluate the issue and make it right.
Exceptions / non-returnable items Certain types of items cannot be returned, like perishable goods (such as food, flowers, or plants), custom products (such as special orders or personalized items), and personal care goods (such as beauty products). We also do not accept returns for hazardous materials, flammable liquids, or gases. Please get in touch if you have questions or concerns about your specific item.
Unfortunately, we cannot accept returns on sale items or gift cards.
Exchanges The fastest way to ensure you get what you want is to return the item you have, and once the return is accepted, make a separate purchase for the new item.
Refunds We will notify you once we’ve received and inspected your return, and let you know if the refund was approved or not. If approved, you’ll be automatically refunded on your original payment method. Please remember it can take some time for your bank or credit card company to process and post the refund too.
You may also like
Effecitive delivery service worldwide
You are assured the best delivery service at Kanozon.com Via Speedaf Express and DHL Express
Satisfied or refunded
Always inform us on time if there is an issue regarding your order
You can get support from our customer service center for any of the product you are looking for at Kanozon.com